Daniel Lee Hunt, jr



Ph.D. University of Mississippi 1999
thesis: Threshold Dose-Response Models in Teratology; Advisors: Eldon Miller & Dale Bowman

area: Statistics

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My current research is in the field of teratology, a division of biostatistics. A teratological experiment is one in which pregnant female animals, usually rats or mice, are exposed to toxic substances. It is expected that the fetuses that these females produce will be affected by the toxic substances. Toxicity endpoints include the number of malformed fetuses, the number of dead fetuses, and the weight of the fetuses. Several assumptions need to be made in order to analyze the toxicity endpoints. One is the distribution of the endpoints. For example, the number of malformed fetuses within a litter could be assumed to follow some type of correlated binomial distribution. Another assumption is the dose response pattern. That is, given a pregnant female's exposure to a dose of a toxic substance, predict the fetal response. My model also assumes the existence of a threshold dose, that is, a dose below which no negative effects can occur.  


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